A test for liver toxicity, using a human liver cell line,.For each compound, the team ran the following tests: Working with a chemistry group led by Julio Alvarez-Builla, PhD, of the University of Alcala in Madrid, Spain, they tested 21 compounds, seeking acetaminophen analogs. This is particularly important in the search for an antipyretic with a safer profile in the COVID-19 pandemic and its associated kidney and liver disease in critically ill SARS-CoV-2 patients.' “They also reduced fever in a pyretic model. 'The new chemical entities reduced pain in 2 in models without the liver and kidney toxicity associated with current over-the-counter analgesics that are commonly used to treat pain-acetaminophen and ,” Nicolas Bazan said in a statement. The team ended up with 2 new chemical entities that reduced pain in modeling studies but without the damage to the liver and renal system, as measured by biomarkers, according to senior author Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans Neuroscience Center of Excellence. Bazan, MD, FACS, a professor in the Department of Surgery and Program Director of the Vascular Surgery Fellowship at Ochsner Clinic, and Surjyadipta Bhattacharjee, PhD, a post-doctoral researcher at the LSU Health New Orleans Neuroscience Center of Excellence, led the team that examined how acetaminophen causes damage-and then set out to find alternatives that did not result in oxidation to N-acetyl-p-benzoquinone imine, or NAPQI, the mechanism that most of results in hepatoxicity from acetaminophen. Doctors and patients need analgesics that go easy on the liver and kidneys but are not addictive, and this week, researchers at LSU Health New Orleans Neuroscience Center of Excellence announced they have discovered a new class of drugs that can do the job. The coronavirus disease 2019 (COVID-19) pandemic presents a new challenge: patients have severe flu-like symptoms, but the virus can also cause renal failure, so acetaminophen is not the best choice. It is toxic for those with compromised liver function, and long-term use can cause liver or kidney damage.

Acetaminophen, sold over the counter worldwide to control pain and reduce fever, is not the harmless drug it appears for every patient.

Side effect of tylenol reserach